orthos-package.Rdorthos decomposes RNA-seq contrasts, for example obtained from a genetic or compound treatment experiments, into non-specific and experiment-specific components. Original and decomposed contrasts can be efficiently queried against a large database of public contrasts (derived from ARCHS4, https://maayanlab.cloud/archs4/) to identify similar experiments. orthos furthermore provides plotting functions to visualize the results of such queries for similar contrasts.